Comparison of In Vitro Activities of the New Triazole SCH56592 and the Echinocandins MK-0991 (L-743,872) and LY303366 against Opportunistic Filamentous and Dimorphic Fungi and Yeasts

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Journal of Clinical Microbiology, October 1998, p. 2950-2956, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Comparison of In Vitro Activities of the New Triazole SCH56592 and the Echinocandins MK-0991 (L-743,872) and LY303366 against Opportunistic Filamentous and Dimorphic Fungi and Yeasts

Ana Espinel-Ingroff^*

Division of Infectious Diseases, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0049

Received 9 April 1998/Returned for modification 5 June 1998/Accepted 23 June 1998

The in vitro antifungal activities of SCH56592, MK-0991, and LY303366 against 83 isolates of Acremonium strictum, Aspergillusflavus, Aspergillus fumigatus, Aspergillus terreus, Bipolarisspp., Blastomyces dermatitidis, Cladophialophora bantiana, Fusariumoxysporum, Fusarium solani, Histoplasma capsulatum, Phialophoraspp., Pseudallescheria boydii, Rhizopus arrhizus, Scedosporiumprolificans, and Sporothrix schenckii were compared. The in vitroactivities of these agents against 104 isolates of yeast pathogensof Candida spp., Cryptococcus neoformans, and Trichosporon beigeliiwere also compared. MICs were determined by following a procedureunder evaluation by the National Committee for Clinical LaboratoryStandards (NCCLS) for broth microdilution testing of the filamentousfungi (visual MICs) and the NCCLS M27-A broth microdilution methodfor yeasts (both visual and turbidimetric MICs). The in vitrofungicidal activity of SCH56592 was superior (minimum fungicidalconcentrations [MFCs], 0.25 to 4 µg/ml for 7 of 18 species tested)to those of MK-0991 and LY303366 (MFCs, 8 to >16 µg/ml for allspecies tested) for the molds tested, but the echinocandins hada broader spectrum of fungicidal activity (MFCs at which 90% ofstrains are inhibited [MFC₉₀s], 0.5 to 4 µg/ml for 6 of 9 speciestested) than SCH56592 (MFC₉₀s, 0.25 to 8 µg/ml for 4 of 9 speciestested) against most of the yeasts tested. Neither echinocandinhad in vitro activity (MICs, >16 µg/ml) against C. neoformansand T. beigelii, while the SCH56592 MICs ranged from 0.12 to 1.0µg/ml for these two species. The MICs of the three agents forthe other species ranged from <0.03 to 4 µg/ml. These resultssuggest that these new agents have broad-spectrum activities invitro; their effectiveness in the treatment of human mycoses isto be determined.

^* Mailing address: Medical College of Virginia of Virginia Commonwealth University, P.O. Box 980049, Richmond, VA 23298-0049.Phone: (804) 828-9711. Fax: (804) 828-3097.

Journal of Clinical Microbiology, October 1998, p. 2950-2956, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

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