JCM Accepts, published online ahead of print on 21 October 2009

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J. Clin. Microbiol. doi:10.1128/JCM.01939-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Changes in Multi-drug Resistance of Enteric Bacteria Following an Intervention to Reduce Antimicrobial Resistance in Dairy Calves

John B. Kaneene^*, Lorin D. Warnick, Carole A. Bolin, Ronald J. Erskine, Katherine May, and RoseAnn Miller

Center for Comparative Epidemiology, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan; the Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York; the Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan; and the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan

^* To whom correspondence should be addressed. Email: kaneene{at}cvm.msu.edu.

An intervention study was conducted to determine whether discontinuing the feeding of milk replacer medicated with oxytetracycline and neomycin to pre-weaned calves reduced antimicrobial resistance in Salmonella, Campylobacter and E. coli. Results found that the intervention did reduce multi-drug resistance in these bacteria, but other factors also influenced multi-drug resistance.