JCM Accepts, published online ahead of print on 4 November 2009

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J. Clin. Microbiol. doi:10.1128/JCM.01687-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Evidence for viral persistence, antiviral resistance and reassortment events in seasonal influenza viruses circulating in Cambodia.

Mathieu Fourment, Sek Mardy, Mey Channa, and Philippe Buchy^*

Institut Pasteur in Cambodia, Virology Unit. 5, Monivong Boulevard, PO Box 983, Phnom Penh, Cambodia; and Department of Biological Sciences, Macquarie University, Sydney NSW 2109, Australia

^* To whom correspondence should be addressed. Email: pbuchy{at}pasteur-kh.org.

The analysis of A/H1N1 and A/H3N2 influenza viruses collected between 2005 and 2008 in Cambodia detected strains resistant to oseltamivir and confirmed widespread resistance to adamantanes. Phylogenetic analyses revealed intra-subtype reassortment, probable re-emergence of A/H3N2 viruses in two consecutive seasons and co-circulation of different lineages in each subtype.