JCM Accepts, published online ahead of print on 21 October 2009

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J. Clin. Microbiol. doi:10.1128/JCM.01257-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Multicenter French prevalence study of non tuberculous mycobacteria in cystic fibrosis

Anne Laure Roux, Emilie Catherinot, Fabienne Rippoll, Nathalie Soismier, Edouard Macheras, Sophie Ravilly, Gil Bellis, Marie-Anne Vibet, Evelyne Le Roux, Lydie Lemonnier, Cristina Guterriez, Véronique Vincent, Brigitte Fauroux, Martin Rottman, Didier Guillemot, Jean-Louis Gaillard^*, and Jean-Louis Herrmann, for the OMA group

EA3647, UFR de Médecine Paris Ile-de-France Ouest, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France; Laboratoire de Microbiologie, Hôpital Raymond Poincaré, Assistance Publique - Hôpitaux de Paris (AP-HP), Garches, France; Laboratoire de Microbiologie, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France; Service de Pneumologie, Hôpital Foch, Suresnes, France; Association Vaincre La Mucoviscidose, Paris, France; Institut National d'Etudes Démographiques, Paris, France; INSERM, U 629, Institut Pasteur, Lille, France; WHO, Geneva, Switzerland; Service de Pneumologie Pédiatrique, Hôpital Armand Trousseau, AP-HP, Paris, France; INSERM, U 657, Paris, France; PhEMI, Institut Pasteur, Paris, France; RISE, UFR de Médecine Paris Ile-de-France Ouest, UVSQ, Guyancourt, France

^* To whom correspondence should be addressed. Email: jean-louis.gaillard{at}apr.aphp.fr.

We performed a multicenter prevalence study of non tuberculous mycobacteria (NTM) involving 1582 patients (mean age, 18.9 years; sex ratio, 1.06) with cystic fibrosis (CF) in France. The overall NTM prevalence (at least one positive culture) was 6.6% (104/1582 patients), ranging from 3.7% (in the East of France) to 9.6% (in the greater Paris area). The Mycobacterium abscessus complex (MABSC, 50 patients) and the Mycobacterium avium complex (MAC, 23 patients) were the most common NTM, and the only ones associated with positive ATS bacteriological criteria for NTM lung disease. The "new" species, Mycobacterium bolletii and Mycobacterium massiliense, accounted for 40% of MABSC isolates. MABSC was isolated at all ages, with a prevalence peak between 11 and 15 years of age (5.8%), while MAC reached its highest prevalence value in patients over 25 years of age (2.2%).